![]() Little is known about how patients might engage, and their potential weight loss achieved, when systems allow for improved access to intensive medical weight loss interventions in primary care. 5, 6, 7 Furthermore, reimbursement remains limited for intensive weight management services. As US obesity rates have climbed, weight loss counseling in primary care has declined and the majority of primary care providers (PCPs) rarely counsel on diet and exercise. ![]() Trial Registrationĭespite known health benefits, 1, 2, 3, 4 weight management treatment infrequently occurs within routine clinical settings. ConclusionsĪccess to a variety of low out-of-pocket cost weight management tools within primary care resulted in ≥ 5% body weight loss in approximately one quarter of low-income patients with obesity. The initially preferred tools were meal replacements, pharmacotherapy, and recreation center passes. Of the on-treatment participants, 34.5% (39 of 113) achieved 5% weight loss. At 12 months, 23.3% (71 of 305) of intervention-eligible participants and 15.7% (415 of 2640) of registry-based comparators had achieved 5% weight loss ( p < 0.001). Overall, 71.3% (305 of 428) had available weight measurement data/PCP visit data to observe the primary outcome. The main secondary outcome was the proportion of on-treatment patients who achieved ≥ 5% weight loss. The primary outcome was the proportion of intervention-eligible patients who achieved ≥ 5% weight loss. Patients chose their tools, could switch tools, and could add a second tool at 6 months. Medical weight management tools-partial meal replacements, recreation center vouchers, pharmacotherapy, commercial weight loss program vouchers, and a group behavioral weight loss program-for $5 or $10 monthly. Participantsįrom a large clinical registry, we randomly selected 428 patients to have the opportunity to receive the intervention. Twelve-month pragmatic clinical weight loss trial with a registry-based comparator group performed in primary care clinics of an urban safety-net hospital. To determine if patients offered low out-of-pocket cost weight management tools achieved more weight loss compared to usual care. Others are mentioned less in the literature, but are just as crucial for the success of a translational research project.There is a need for new strategies to improve the success of obesity treatment within the primary care setting. Some of the commandments deal with topics that are currently in the spotlight, such as machine readability, the FAIR Guiding Principles and the GDPR regulations. These commandments are not only useful for the data managers, but for all involved in a translational research project. ![]() The author has worked on the information technology infrastructure for several translational research projects in oncology for the past nine years, and presents his lessons learned in this paper in the form of ten commandments. This informatics, which includes data management, data stewardship and data governance, enables researchers to store and analyze their ‘big data’ in a meaningful way, and enable application in the clinic. The success of translational research projects often does not depend only on the fundamental science and the applied science, but also on the informatics needed to connect everything: the translational research informatics. To cross the valley of death, fundamental researchers need to collaborate with clinical researchers and with industry so that promising results can be implemented in a product. This “translation” is often not easy, because it means that the so-called “valley of death” will need to be crossed: many interesting findings from fundamental research do not result in new treatments, diagnostics and prevention. In translational research projects, academia and industry work together to improve healthcare, often through public-private partnerships. Translational research applies findings from basic science to enhance human health and well-being.
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